Breast - nonmalignant
Benign tumors / changes
Syringomatous adenoma of nipple

Author: Hind Nassar, M.D. (see Authors page)

Revised: 14 August 2017, last major update April 2010

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Syringomatous adenoma nipple

Cite this page: Nassar, H. Syringomatous adenoma of nipple. website. Accessed November 18th, 2017.
Definition / general
  • Also called infiltrating syringomatous adenoma of nipple, syringomatous tumor (AFIP fascicle, 4th series)
  • Rare
  • Median age 36 years but wide range
  • May originate from sweat glands of nipple areola complex
Clinical features
  • Benign but locally infiltrative
  • Resembles syringomatous tumors of lip, salivary glands, head and neck
Case reports
  • Excision with adequate margins (may require nipple resection)
  • May recur if incompletely excised
Gross description
  • Subareolar, 2 - 4 cm, ill defined, firm gray tan tissue, may have small cystic areas
Gross images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Microscopic (histologic) description
  • Haphazard proliferation of oval / elongated ductules and tubules composed of small basophilic cells infiltrating dermis of skin, nipple stroma and nipple smooth muscle bundles, resembling cutaneous syringoma
  • Ducts have teardrop, comma or branching shapes with open lumens
  • Fibrous stroma
  • Perineural invasion common
  • Variable squamous metaplasia with keratinizing cysts and calcification
  • No apparent myoepithelial cells (but identifiable with immunostains), no intraductal hyperplasia, no atypia, no / rare mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Perineurial invasion, contributed by Dr. Mark R. Wick

Keratinization in syringomatous duct

Images hosted on other servers:

Acanthotic epidermis

Small, solitary, evenly spaced duct-like structures

Layers of cuboidal or squamoid epithelial cells

Small, dark tumor cells

Keratotic cysts

Comma shaped tubules

Various images

Positive stains
Differential diagnosis