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Breast-nonmalignant
Benign tumors / changes
Spindle cell lipoma / pleomorphic lipoma
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 8 October 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Lipoma with thin, uniform spindle cells associated with collagen bundles; also mature adipocytes and entrapped normal parenchyma
Terminology
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● Also called benign stromal spindle cell tumor with predominant adipocytic component (AFIP fascicle, 4th series)
Epidemiology
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Sites
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Etiology
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● Related to myofibroblastoma (Am J Surg Pathol 2001;25:1022) and solitary fibrous tumor / hemangiopericytoma; all are benign stromal spindle cell tumors with similar immunohistochemistry, which vary based on predominant cell type present
Clinical features
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Prognostic factors
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Case reports
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● 28 year old woman with deep tumor of breast (Pathology 1999;31:288)
● 48 year old woman with 3 cm tumor (Indian J Pathol Microbiol 2008;51:234)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Other images: white fibrous tumor intermingling with breast tissue
Micro description (Histopathology)
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● Thin, uniform spindle cells associated with collagen bundles, mature adipocytes and entrapped normal parenchyma, resembling an ● infiltrating malignancy
● Nuclei are evenly spaced, regular, elongated and ovoid
● Pleomorphic lipomas have prominent floret cells
Micro images
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Spindle cells associated Cytology, H&E, CD34
with collagen and adipose
Spindle cells Spindle cells are Spindle cells are smooth
are CD34+ desmin negative muscle actin negative
Virtual Slides
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Videos
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Cytology description
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● Pleomorphic lipoma - floret cells and mononuclear hyperchromatic cells with scalloped nuclei, which appear malignant (Acta Cytol 2000;44:255)
Cytology images
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Positive stains
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● CD34, vimentin
Negative stains
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● Keratin, S100, desmin, smooth muscle actin
● Factor VIII
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Spindle cell lipoma / pleomorphic lipoma
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