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Breast-nonmalignant
Inflammatory / infectious
Sclerosing mastitis, IgG4 related
Reviewer:
Revised: 8 April 2010, last major update April 2010
Copyright: (c) 2010, PathologyOutlines.com, Inc.
Definition
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● Newly described member of IgG4 related sclerosing diseases
Terminology
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Epidemiology
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● In study of 4 women, mean age 47 years
Etiology
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● IgG4-related sclerosing disease is a recently described syndrome of mass forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, with high serum IgG4 titers, increased IgG4 plasma cells, good clinical outcome
● Also causes mastitis (Am J Surg Pathol 2009;33:1058)
Clinical features
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● Painless breast masses
Prognostic factors
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Case reports
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Treatment
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● No recurrence in small study
Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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Micro images
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● Loss of lobules due to dense lymphoplasmacytic infiltrates and prominent stromal sclerosis
● Variable phlebitis
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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● Numerous IgG4 plasma cells
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Inflammatory / infectious > Sclerosing mastitis
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