Home   Chapter Home   Jobs   Conferences   Fellowships   Books

 

 

Advertisement 

 

Breast-nonmalignant

Inflammatory / infectious

Reactive spindle cell nodule

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 28 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

=========================================================================

● Benign spindle cell tumor, rare complication of breast core biopsy or fine needle aspiration (Am J Clin Pathol 1991;96:76)

● Similar to counterparts in bladder, prostate or other GU sites, but few publications in breast

 

Terminology

=========================================================================

 

Epidemiology

=========================================================================

 

Sites

=========================================================================

 

Etiology

=========================================================================

● May be due to exuberant reparative process

 

Clinical features

=========================================================================

● Associated with biopsy of complex sclerosing lesions and papillary lesions (Am J Clin Path 2000;113:288)

 

Prognostic factors

=========================================================================

 

Case reports

=========================================================================

● 52 year old woman with mass arising post-Mammotome (Pathol Int 2008;58:787)

 

Treatment

=========================================================================

 

Clinical images

=========================================================================

 

Gross description (Macroscopy)

=========================================================================

● Up to 1 cm, nodular, not encapsulated

 

Gross images

=========================================================================

 

 

Micro description (Histopathology)

=========================================================================

● Myofibroblastic spindle cells with mild/moderate nuclear pleomorphism, small vessel proliferation, foam cells, lymphocytes, hemosiderin

 

Micro images

=========================================================================

 

Bladder: myofibroblasts in

myxoid matrix

 

Drawings

=========================================================================

 

Virtual Slides

=========================================================================

 

Videos

=========================================================================

 

Cytology description

=========================================================================

 

Cytology images

=========================================================================

 

Positive stains

=========================================================================

Spindle cells:

● Smooth muscle actin, muscle specific actin

 

Negative stains

=========================================================================

 

Electron microscopy descriptions

=========================================================================

 

Electron microscopy images

=========================================================================

 

Molecular / cytogenetics description

=========================================================================

 

Molecular / cytogenetics images

=========================================================================

 

 

Differential Diagnosis

=========================================================================

Fibromatosis: spindle cells form interlacing fascicles with variable collagen deposition and cellularity; usually extends into surrounding fat and glandular parenchyma

Inflammatory myofibroblastic tumor: prominent inflammatory infiltrate, not post-operative

Leiomyosarcoma: no recent history of biopsy or surgery; often marked atypia and necrosis

Low grade sarcoma

Low grade spindle cell carcinoma

Myofibroblastoma: uniform, bland spindle cells haphazardly arranged in fascicles with pushing borders, separated by broad bands of hyalinized collagen

Nodular fasciitis: superficial, well circumscribed, zonation effect with hypocellular central region and hypercellular periphery; feathery, tissue-culture like growth pattern due to abundant ground substance; often with mucoid pools (microcysts)

 

Additional references

=========================================================================

 

End of Breast-nonmalignant > Inflammatory / infectious > Reactive spindle cell nodule

 

 

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.

 

All information on this website is protected by copyright of PathologyOutlines.com, Inc.  Information from third parties may also be protected by copyright.  Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).