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Breast-nonmalignant
Inflammatory / infectious
Nephrogenic systemic fibrosis
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 28 September 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Recently described systemic fibrosing disorder primarily affecting patients with chronic renal insufficiency exposed to gadolinium-based contrast agents (Clin J Am Soc Nephrol 2010;5:484, International Center)
● Skin involvement may resemble peau d'orange
● Only one case reported to date involving breast
Terminology
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● Previously called nephrogenic fibrosing dermopathy
Epidemiology
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Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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● 61 year old woman with end stage renal disease and bilateral breast changes resembling inflammatory carcinoma (Arch Pathol Lab Med 2007;131:145)
Treatment
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● Possibly rapamycin (J Am Acad Dermatol 2010;62:343)
Clinical images
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Thickened skin over arm
Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Fibrocollagenous thickening of dermis with clefts in reticular dermis and perivascular plasmacytic dermal infiltrate
Micro images
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Fibrocollagenous thickening of dermis Fibroblast like cells and stromal mucin
with clefts in reticular dermis and (Alcian blue+); spindle cells are
perivascular plasmacytic dermal infiltrate CD68+ and CD34+
Various images (not breast)
Other images (not breast): #1; #2; #3; #4; #5
Drawings
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Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Inflammatory / infectious > Nephrogenic systemic fibrosis
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