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Breast-nonmalignant

Inflammatory / infectious

Nephrogenic systemic fibrosis

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 28 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Recently described systemic fibrosing disorder primarily affecting patients with chronic renal insufficiency exposed to gadolinium-based contrast agents (Clin J Am Soc Nephrol 2010;5:484, International Center)

● Skin involvement may resemble peau d'orange

● Only one case reported to date involving breast

 

Terminology

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● Previously called nephrogenic fibrosing dermopathy

 

Epidemiology

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Sites

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Etiology

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Clinical features

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Prognostic factors

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Case reports

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● 61 year old woman with end stage renal disease and bilateral breast changes resembling inflammatory carcinoma (Arch Pathol Lab Med 2007;131:145)

 

Treatment

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● Possibly rapamycin (J Am Acad Dermatol 2010;62:343)

 

Clinical images

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Thickened skin over arm

 

Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Fibrocollagenous thickening of dermis with clefts in reticular dermis and perivascular plasmacytic dermal infiltrate

 

Micro images

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Fibrocollagenous thickening of dermis                        Fibroblast like cells and stromal mucin

with clefts in reticular dermis and                                 (Alcian blue+); spindle cells are

perivascular plasmacytic dermal infiltrate                 CD68+ and CD34+

 

 

Various images (not breast)

 

Other images (not breast): #1#2#3#4#5  

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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Wikipedia

 

End of Breast-nonmalignant > Inflammatory / infectious > Nephrogenic systemic fibrosis

 

 

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.

 

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