Breast – Malignant, Males, Children - WHO histological classification of tumours of the breast

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Breast-malignant, males, children

WHO histological classification of tumors of the breast

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 4 September 2009

Last major update: September 2009

Background

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● Reflects views of Working Groups that convened in Lyon, France in January and March 2002

● Publication: Tavassoli: Tumours of the Breast and Female Genital Organs (WHO, 2003)

● Also listed below are ICD-O (morphology code) and behavior code: /0 for benign, /1 for borderline or uncertain, /2 for in situ and grade 3 intraepithelial neoplasia, /3 for malignant

Epithelial Tumors

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● Invasive ductal carcinoma, not otherwise specified (NOS) - 8500/3

Mixed type carcinoma

Pleomorphic carcinoma - 8022/3

Carcinoma with osteoclastic giant cells - 8035/3

Carcinoma with choriocarcinomatous features

Carcinoma with melanotic features

● Invasive lobular carcinoma - 8520/3

● Tubular carcinoma - 8211/3

● Invasive cribriform carcinoma - 8201/3

● Medullary carcinoma - 8510/3

● Mucinous carcinoma and other tumours with abundant mucin

Mucinous carcinoma - 8480/3

Cystadenocarcinoma and columnar cell mucinous carcinoma - 8480/3

Signet ring cell carcinoma - 8490/3

● Neuroendocrine tumours

Solid neuroendocrine carcinoma

Atypical carcinoid tumour - 8249/3

Small cell / oat cell carcinoma - 8041/3

Large cell neuroendocrine carcinoma - 8013/3

● Invasive papillary carcinoma - 8503/3

● Invasive micropapillary carcinoma - 8507/3

● Apocrine carcinoma - 8401/3

● Metaplastic carcinomas - 8575/3

Pure epithelial metaplastic carcinomas - 8575/3

Squamous cell carcinoma - 8070/3

Adenocarcinoma with spindle cell metaplasia - 8572/3

Adenosquamous carcinoma - 8560/3

Mucoepidermoid carcinoma - 8430/3

Mixed epithelial/mesenchymal metaplastic carcinomas - 8575/3

● Lipid-rich carcinoma - 8314/3

● Secretory carcinoma - 8502/3

● Oncocytic carcinoma - 8290/3

● Adenoid cystic carcinoma - 8200/3

● Acinic cell carcinoma - 8550/3

● Glycogen-rich clear cell carcinoma - 8315/3

● Sebaceous carcinoma - 8410/3

● Inflammatory carcinoma - 8530/3

● Lobular neoplasia

Lobular carcinoma in situ - 8520/2

● Intraductal proliferative lesions

Usual ductal hyperplasia

Flat epithelial atypia

Atypical ductal hyperplasia

Ductal carcinoma in situ - 8500/2

● Microinvasive carcinoma

● Intraductal papillary neoplasms

Central papilloma - 8503/0

Peripheral papilloma - 8503/0

Atypical papilloma

Intraductal papillary carcinoma - 8503/2

Intracystic papillary carcinoma - 8504/2

● Benign epithelial proliferations

Adenosis including variants: sclerosing adenosis, apocrine adenosis, blunt duct adenosis,

microglandular adenosis, adenomyoepithelial adenosis

Radial scar / complex sclerosing lesion

Adenomas

Tubular adenoma - 8211/0

Lactating adenoma - 8204/0

Apocrine adenoma - 8401/0

Pleomorphic adenoma - 8940/0

Ductal adenoma - 8503/0

Myoepithelial lesions

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● Myoepitheliosis

● Adenomyoepithelial adenosis

● Adenomyoepithelioma - 8983/0

● Malignant myoepithelioma - 8982/3

Mesenchymal Tumors

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● Hemangioma - 9120/0

● Angiomatosis

● Haemangiopericytoma - 9150/1

● Pseudoangiomatous stromal hyperplasia

● Myofibroblastoma - 8825/0

● Fibromatosis (aggressive) - 8821/1

● Inflammatory myofibroblastic tumour - 8825/1

● Lipoma - 8850/0

Angiolipoma - 8861/0

● Granular cell tumour - 9580/0

● Neurofibroma - 9540/0

● Schwannoma - 9560/0

● Angiosarcoma - 9120/3

● Liposarcoma - 8850/3

● Rhabdomyosarcoma - 8900/3

● Osteosarcoma - 9180/3

● Leiomyoma - 8890/0

● Leiomyosarcoma - 8890/3

Fibroepithelial Tumors

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● Fibroadenoma - 9010/0

● Phyllodes tumour - 9020/1

Benign - 9020/0

Borderline - 9020/1

Malignant - 9020/3

● Periductal stromal sarcoma, low grade - 9020/3

● Mammary hamartoma

Tumors of the nipple

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● Nipple adenoma - 8506/0

● Syringomatous adenoma - 8407/0

● Paget disease of the nipple - 8540/3

Malignant lymphoma

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● Diffuse large B cell lymphoma - 9680/3

● Burkitt lymphoma - 9687/3

● Extranodal marginal-zone B-cell lymphoma of MALT type - 9699/3

● Follicular lymphoma - 9690/3

Metastatic tumors - Tumors of the male breast

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● Gynaecomastia

● Carcinoma

Invasive - 8500/3

In situ - 8500/2

End of Breast – Malignant, Males, Children > WHO histological classification of tumors of the breast

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