Breast malignant, males, children
Treatment effect - Radiation therapy

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 21 December 2016, last major update August 2012

Copyright: (c) 2001-2016,, Inc.

PubMed Search: radiation therapy effects breast

See also Atypical or benign vascular lesion, post radiation
Cite this page: Treatment effect - Radiation therapy. website. Accessed July 21st, 2017.
Case reports
Microscopic (histologic) description
  • Giant tumor cells with bizarre nuclear changes (J Clin Pathol 1990;43:152), naked nuclei and abnormal mitotic figures
  • Extensive tumor necrosis demarcated by thick fibrous walls
  • Changes in nonneoplastic breast include atypia, lobular sclerosis and atrophy (may distort lobular architecture and obscure myoepithelial cells, Hum Pathol 1984;15:545), intimal thickening in small muscular arteries (Radiother Oncol 2009;92:477) and fat necrosis, but usually no mitotic activity or loss of polarity
  • Changes do not regress over time (Am J Surg Pathol 2004;28:47)
Microscopic (histologic) images

Images hosted on PathOut server:

Thickened basement membranes

Atypical stromal fibroblasts

LCIS unchanged by
radiation compared
to atrophic
normal glands

Collagenization of
intralobular stroma and
glandular atrophy (AFIP)

Images hosted on other servers:

Large stromal
fibroblasts may
also occur in
nonirradiated tissue

Atypia in normal duct

Atypia within normal lobule

Fat necrosis post-iridium implant

Vessel shows reduplicated
elastic lamina and intimal
thickening (elastin stain)

Radiation induced epithelial atypia



Atypical stromal cells,
lymphocytic infiltrate and
increased collagen bundles

Virtual slides
Differential diagnosis