Breast malignant, males, children
Treatment effect - Chemotherapy

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 21 December 2016, last major update August 2012

Copyright: (c) 2001-2016,, Inc.

PubMed Search: breast chemotherapy effect
Cite this page: Treatment effect - Chemotherapy. website. Accessed March 29th, 2017.
Clinical Features
Case Reports
Micro Description
  • Smaller tumor size, reduced cellularity, generally same morphology and tumor markers (may change rarely)
  • Extensive cytoplasmic vacuolization causing tumor cells to resemble histiocytes
  • Also tumor necrosis, atrophy and marked nuclear atypia (enlarged, bizarre shapes) in a background of chronic inflammation with hemosiderin laden macrophages and fibrosis; similar changes in lymph nodes (Histopathology 1996;29:63, Pathol Res Pract 1997;193:187)
  • May show distortion of glandular architecture, eosinophilic change, decreased mitotic activity (Arch Pathol Lab Med 2009;133:633)
Micro Images

Images hosted on PathOut server:

Residual tumor cells have bizarre shapes with enlarged hyperchromatic nuclei and cytoplasmic vacuoles

Post-chemotherapy specimen
has only scattered tumor cells
in collagenous stroma (AFIP)

Images hosted on other servers:

Various images

Post-chemotherapy fibrosis

Scar and foamy histiocytes

Foamy histiocytes and lymphocytes

Chemoresistant tumor cells with widespread lymphovascular invasion in both breast and axillary - no apparent treatment effect, Contributed by Dr. Semir Vranic, University of Sarajevo (Bosnia)