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Breast malignant, males, children

Carcinoma subtypes

Tall-cell like tumors


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 4 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Definition
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● Very rare tumor resembling tall cell variant of papillary thyroid carcinoma, first described in 2003 (Am J Surg Pathol 2003;27:1114)

Terminology
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● Not part of WHO breast classification

Clinical features
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● Presents with palpable nodule
● May have nodal metastases (Int J Surg Pathol 2007;15:14)

Micro description
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● Solid or papillary nests of columnar / cuboidal cells with eosinophilic granular cytoplasm, round / oval nuclei with sharply defined nuclear membrane, nuclear grooves and eosinophilic pseudoinclusions
● Also psammoma bodies

Cytology description
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● Abundant cellularity with isolated cells, sheets and papillary formations of epithelial cells with nuclear grooves (Int J Surg Pathol 2006;14:79)

Positive stains
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● Keratin, ER (alpha and beta), PR
● Also androgen receptor, CEA, bcl2

Negative stains
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● Thyroglobulin, TTF1

Molecular description
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● No BRAF mutations of thyroid carcinoma

Electron microscopy description
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● Cytoplasmic granules are mitochondria

Differential diagnosis
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● Metastatic tall cell variant of papillary thyroid carcinoma: clinical history of thyroid disease, thyroglobulin+, TTF1+ (Ann Pathol 1998;18:130)

End of Breast malignant, males, children > Carcinoma subtypes > Tall-cell like tumors


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