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Breast-malignant, males, children
Tall-cell like tumors of breast
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 21 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Resembles tall cell variant of papillary thyroid carcinoma (AJSP 2003;27:1114)
● Very rare
Terminology
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● Not part of WHO breast classification
Clinical
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● Presents with palpable nodule
● May have nodal metastases (Int J Surg Pathol 2007;15:14)
Microscopic description
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● Breast tumors with solid or papillary nests of columnar/cuboidal cells with eosinophilic granular cytoplasm, round/oval nuclei with sharply defined nuclear membrane, nuclear grooves and eosinophilic pseudoinclusions
● Also psammoma bodies
Cytology description
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● Abundant cellularity with isolated cells, sheets, and papillary formations of epithelial cells with nuclear grooves (Int J Surg Pathol 2006;14:79)
Positive stains
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● Keratin, ER (alpha and beta), PR
● Also androgen receptor, CEA, bcl2
Negative stains
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● Thyroglobulin, TTF1
Molecular / cytogenetics
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● No BRAF mutations of thyroid carcinoma
Electron microscopy
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● Cytoplasmic granules are mitochondria
Differential diagnosis
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● Metastatic tall cell variant of papillary thyroid carcinoma - clinical history of thyroid disease, thyroglobulin+, TTF1+ (Ann Pathol 1998;18:130)
End of Breast – Malignant, Males, Children > Tall-cell like tumors of breast
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