Breast – Malignant, Males, Children - Suspicious for microinvasion

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Breast-malignant, males, children

Suspicious for microinvasion

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 13 September 2009

Last major update: September 2009

Clinical

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● In one study, 90% of core biopsies that were suspicious for invasion had definitive invasive disease at excision (Ann Surg Oncol 2007;14:704)

Micro description

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● Periductal or perilobular stroma contains either isolated individual neoplastic cells or rare clusters of cells thought to be neoplastic, but review of multiple levels fails to demonstrate continuity of cells/groups with adjacent in situ neoplasm or underlying residual epithelial structures

Micro images

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Various images (fig B, C, D)

Positive stains

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● Myoepithelial cells (favor noninvasive process) - p63 (sensitive and specific), smooth muscle actin (also stains myofibroblasts), calponin, smooth muscle myosin heavy chain

● Basement membrane - type IV collagen, laminin

Additional references

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● Mod Path 2002;15:95 (core biopsies), AJSP 2004;28:1076 (immunostains), AJSP 2003;27:82 (immunostains)

End of Breast – Malignant, Males, Children > Suspicious for microinvasion

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