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Breast-malignant, males, children
Morphologic variants of DCIS
Squamous cell carcinoma in situ / Bowen’s disease
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 30 August 2009
Last major update: August 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Either intraepidermal tumor of nipple, or rarely a tumor of breast parenchyma (AJSP 2007;31:1414)
Case reports
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● 69 year old woman with coexisting basaloid carcinoma of nipple (Breast J 2009;15:409)
● Tumor of nipple (Hum Path 1994;25:1371)
● Tumor of nipple in young man with HIV (Clin Breast Cancer 2009;9:53)
Treatment and prognosis
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● Nipple tumor - wide local excision, possibly phototherapy (Breast 2005;14:65)
● Breast parenchyma tumor - standard treatment for DCIS (excision, possible radiotherapy)
Microscopic description / grading
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● Obvious squamous features with diffuse atypia
● May be extensive, but no dermal or myoepithelial invasion
Micro images
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Contributed by Dr. Amy Lynn, Toledo, Ohio - skin (not necessarily breast)
Positive stains
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● High molecular weight keratin
Negative stains
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● Mucin, melanin
Differential diagnosis
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● Paget’s disease (CK7+, CAM5.2+, J Cutan Pathol 2003;30:449)
End of Breast – Malignant, Males, Children > Squamous cell carcinoma in situ / Bowen’s disease
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