Breast – Malignant, Males, Children

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Breast-malignant, males, children

Morphologic variants of DCIS

Solid DCIS

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 30 August 2009

Last major update: August 2009

Microscopic description

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● Glandular lumen is filled by small to medium, uniform cells without necrosis

● May produce a microacinar or rosette-like pattern

● Cells are larger than LCIS but smaller and more uniform than comedocarcinoma

● Often pale cytoplasm with sharply outlined cell borders

● May contain secretions but no necrosis

● Usually but not always low grade (Anal Quant Cytol Histol 2001;23:418)

Drawings

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Drawing

Micro images

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AFIP images: solid growth pattern with occlusion and distension of ducts by proliferation of cells with prominent nuclear pleomorphism (note: high grade features are not common in solid DCIS)

Various images

Solid pattern with central mucin

Intermediate grade based on cytologic features

High grade (basal phenotype)

Differential diagnosis

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● Lobular carcinoma in situ - sharp cell borders, necrosis, microacini, E-cadherin negative (Semin Diagn Pathol 2004;21:25)

● Carcinoid tumor - chromatin has salt and pepper pattern, usually other neuroendocrine features

End of Breast – Malignant, Males, Children > Solid DCIS

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