Table of ContentsDefinition / general | Microscopic (histologic) description | Positive stains | Differential diagnosis
Cite this page: Signet ring cell DCIS. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantsignetringcellDCIS.html. Accessed November 22nd, 2017.
Definition / general
Microscopic (histologic) description
- Cells have eccentric nuclei that are indented at the nuclear border by a cytoplasmic vacuole with a central minute secretion droplet
- Clear cells of normal nipple-areola complex: varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)
- Histiocytes: may appear in lymph nodes too; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)
- Non-specific cytoplasmic halos: usually a fixation artifact, mucin negative