Breast – Malignant, Males, Children

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Breast-malignant, males, children

Morphologic variants of DCIS

Signet ring cell DCIS

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 19 August 2009

Last major update: August 2009

Definition

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● Not a distinct subtype of DCIS (Am J Clin Pathol 1980;73:31, Cancer 1985;55:2533)

● Signet ring cells are seen in neuroendocrine DCIS, LCIS and secretory carcinoma

● Considered high grade (grade 3) by definition

Positive stains

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● Alcian plus, PAS-diastase

Differential diagnosis

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● Clear cells of normal nipple-areola complex - varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)

● Fixation artifact - mucin negative

● Histiocytes - may appear in lymph nodes also; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)

End of Breast – Malignant, Males, Children > Signet ring cell DCIS

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