Breast – Malignant, Males, Children - Breast cancer - Prognostic factors

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Breast-malignant, males, children

Breast cancer - Prognostic factors - Fibrotic focus

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 20 September 2009

Last major update: September 2009

Fibrotic focus

Definition

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● Mixture of fibroblasts and collagen fibers that may occupy almost the entire center of an invasive ductal carcinoma, replacing the necrotic central area (see also central acellular subtype)

● May be due to intratumoral hypoxia (Histopathology 2007;51:440), leading to clonal heterogeneity of tumor cells (Mod Path 2001;14:325)

● Invasive ductal carcinomas with fibrotic focus have poorer survival than those without (Mod Path 2002;15:502, Jpn J Cancer Res 1997;88:590); also predicts bone metastases (Hum Path 2008;39:681)

● Associated with basal-like subtype, activated wound-healing signature and a poor prognosis 76-gene signature (Clin Cancer Res 2008;14:2944)

Micro images

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Various images

Low power

MIB1+ fibroblasts

End of Breast – Malignant, Males, Children > Breast cancer - Prognostic factors > Fibrotic focus

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