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Breast-malignant, males, children
Oncocytic carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 20 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Composed of 70%+ oncocytic cells
● Also called malignant oncocytoma
Epidemiology
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● Very rare (<20 cases reported), usually age 60+ years
Case reports
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● 46 year old woman (Zentralbl Allg Pathol 1987;133:279)
● 70 year old woman (Zentralbl Allg Pathol 1989;135:357)
● 76 year old man (Archives 1989;113:1396)
Microscopic description
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● Well circumscribed, abundant granular eosinophilic cytoplasm, low grade nuclei with conspicuous nucleolus (AJSP 1998;22:221)
● Similar to apocrine carcinoma on H&E, but different staining pattern
● No/rare mitotic figures
Micro images
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Oncocytic features
Positive stains
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● Anti-mitochondrial antibody
Negative stains
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● GCDFP-15
Electron microscopy
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● Numerous mitochondria dispersed throughout cell, occupying 60%+ of cytoplasm
Differential diagnosis
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● Tumors of apocrine differentiation - GCDFP-15+, negative for antimitochondrial antibody
Additional references
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End of Breast – Malignant, Males, Children > Oncocytic carcinoma
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