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Breast-malignant, males, children
Solid type, neuroendocrine carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 20 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Neuroendocrine carcinomas have 50%+ neuroendocrine differentiation, based on chromogranin or synaptophysin staining
Terminology
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● This is a distinct WHO diagnostic category
Clinical
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● May have similar clinical features to breast carcinoma in general (Oncol Rep 2008;20:1369)
Case reports
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● 40 year old woman (Breast Cancer 2007;14:250)
● 60 year old woman with breast tumor metastatic to renal cell carcinoma (Pathol Res Pract 2008;204:851)
● Elderly man (Ultrastruct Pathol 1993;17:115
Microscopic description
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● Densely cellular, solid nests and trabeculae or spindled, plasmacytoid or large cell cells, separated by a delicate fibrovascular stroma
● Rarely rosettes or other features resembling carcinoid tumor
● May originate from solid papillary DCIS, or resemble alveolar subtype of lobular carcinoma
Micro images
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Various stains Chromogranin
(fig a, b, g, h, i)
Cytology
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● Dyscohesive polygonal cells with abundant cytoplasm, many containing eosinophilic granules located at one pole (Malays J Pathol 2008;30:57)
End of Breast – Malignant, Males, Children > Neuroendocrine carcinoma > solid type
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