Table of ContentsDefinition / General | Terminology | Case Reports | Treatment | Clinical Images | Micro Description | Micro Images | Differential Diagnosis
Cite this page: Neuroendocrine carcinoma - large cell. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantneuroendocrinelargecell.html. Accessed January 22nd, 2017.
Definition / General
- Rare; poorly differentiated tumor composed of large, crowded clusters of cells with moderate / abundant cytoplasm, nuclei with vesicular or finely granular chromatin and frequent mitotic figures (18+ / 10 HPF)
- Part of WHO classification
- Aggressive tumor requiring multimodal treatment
- Neuroendocrine differentiation morphologically and by immunohistochemistry; larger cell size than small cell carcinoma; frequent necrosis