Breast – Malignant, Males, Children - Large cell neuroendocrine carcinoma

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Breast-malignant, males, children

Large cell neuroendocrine carcinoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 23 September 2009

Last major update: September 2009

Definition

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● Rare; poorly differentiated tumor composed of crowded, large clusters of cells with moderate/abundant cytoplasm, nuclei with vesicular or finely granular chromatin, frequent mitotic figures (18+/10 HPF)

Terminology

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● Part of WHO classification

Case reports

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● 27 year old woman (J Korean Med Sci 2008;23:1118)

● 63 year old woman (Breast Cancer 2009 Aug 11 [Epub ahead of print])

Microscopic description

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● Neuroendocrine differentiation morphologically and by immunohistochemistry; frequent necrosis

Microscopic images

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Nests of large tumor cells Chromogranin+

Differential diagnosis

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● Metastatic carcinoid tumor or small cell carcinoma

End of Breast – Malignant, Males, Children > Large cell neuroendocrine carcinoma

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