Breast – Malignant, Males, Children - Mucoepidermoid carcinoma

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Breast-malignant, males, children

Mucoepidermoid carcinoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 14 September 2009

Last major update: September 2009

Terminology

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● Also called adenosquamous carcinoma, adenoacanthoma

Clinical

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● Very rare

● Grading system used for salivary gland tumors is recommended (Virchows Arch 2004;444:13)

Case reports

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● 46 year old woman with high grade tumor and axillary metastases (Archives 1981;105:612)

● 54 year old woman (Pathol Int 2006;56:549)

● Low grade tumors (Archives 1979;103:196)

● High grade and low grade tumors (Neoplasma 2007;54:168)

Microscopic description

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● Resembles salivary gland counterpart (Virchows Arch 2004;444:13)

● Mixture of neoplastic mucus-secreting, squamous and intermediate cells

Micro images

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Salivary gland tumors

Alcian blue-PAS

Cytology description

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● High grade tumors - clusters of epithelial ductal cells with mixed glandular, squamous and intermediate cells; may be scant intra- and extracellular mucin (Acta Cytol 2006;50:344)

Positive stains

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● Keratin, EMA, CEA

● Mucin is PAS+

Electron microscopy

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● Intermediate cells are modified myoepithelial cells (Hum Path 1985;16:941)

Differential diagnosis

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● Metastatic salivary gland tumor (Acta Cytol 2002;46:377)

End of Breast – Malignant, Males, Children > Mucoepidermoid carcinoma

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