Breast malignant, males, children
Carcinoma subtypes
Mucinous cystadenocarcinoma and columnar cell mucinous carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 December 2016, last major update September 2012

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PubMed search: mucinous cystadenocarcinoma breast and columnar cell mucinous [title] carcinoma breast

Cite this page: Mucinous cystadenocarcinoma and columnar cell mucinous carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantmucinouscystadenocarcinoma.html. Accessed March 29th, 2017.
Definition / General
  • Very rare as primary breast tumor (< 50 cases reported)
  • Carcinoma composed of tall columnar cells with basal, bland nuclei and abundant intracytoplasmic and extracytoplasmic mucin (as opposed to mucinous / colloid carcinoma with only extracellular mucin, and signet ring cell carcinoma with only intracellular mucin)
  • Either grossly cystic (mucinous cystadenocarcinoma) or solid (columnar cell mucinous carcinoma)
  • Resembles similar tumors of ovary, pancreas and appendix (Am J Surg Pathol 1998;22:698)
Epidemiology
  • Mean age 58 - 68 years, range 49 - 96 years
Case Reports
Gross Description
  • Multicystic, up to 19 cm
  • Resembles ovarian and pancreatic cystadenocarcinoma, cystic hypersecretory carcinoma of breast
Gross Images

Images hosted on other servers:

Ovary - multicystic tumor

Micro Description
  • Cystic spaces lined by bland, tall columnar cells with abundant intracytoplasmic mucin
  • Tumor cells exhibit stratification, tufting and papillary formation
  • Variable cytologic atypia
  • Gradual loss of intracytoplasmic mucin and transformation to eosinophilic squamoid cells that are focally invasive
  • Columnar cell variant has round and convoluted glands in loose aggregates, lined by tall columnar mucinous epithelium with basal bland nuclei
  • Demonstrates both intracellular and extracellular mucin
Micro Images

Images hosted on other servers:

Mucinous cystadenocarcinoma of breast with estrogen receptor expression

Breast - various images

Retroperitoneal tumor

Positive Stains
Negative Stains
Differential Diagnosis