Breast – Malignant, Males, Children

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Breast-malignant, males, children

Morphologic variants of DCIS

Mucinous DCIS

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 15 August 2009

Last major update: August 2009

Definition

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● DCIS associated with invasive mucinous carcinoma or DCIS with mucin production

● Mucin is usually in lumens of ducts involved by DCIS; also in vessels

● There are few studies of this entity (Histopathology 1996;29:533)

Epidemiology

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● Mean age 62 years

● Predominant histologic types are solid, cribriform and micropapillary

● DCIS grading - low grade/1 (29%), intermediate grade/2 (61%), high grade/3 (10%)

Clinical

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● Often associated with neovascularization in intraluminal mucin, although the presence of vascularized mucin in a needle biopsy cannot differentiate between in situ and invasive disease (Histopathology 2008;53:545)

Micro images

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DCIS (micropapillary)

with invasive mucinous

carcinoma

Differential diagnosis

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● Invasive mucinous carcinoma - mucin is in direct contact with stroma, and tumor cells are floating in mucin

End of Breast – Malignant, Males, Children > Mucinous DCIS

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