Breast – Malignant, Males, Children - Mixed ductal and lobular carcinoma

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Breast-malignant, males, children

Mixed ductal and lobular carcinoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 15 September 2009

Last major update: September 2009

Definition

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● Mixture of ductal NOS and lobular carcinomas

● No distinct clinical features (Breast Cancer Res Treat 2009;114:243)

Terminology

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● Not part of WHO breast classification

Epidemiology

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● 4% of breast carcinomas

● 89% have DCIS, 31% have LCIS

● 41% have positive lymph nodes at diagnosis

Microscopic description

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● Definite features of invasive ductal carcinoma and invasive lobular carcinoma in same tumor

Micro images

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Various images E-cadherin staining

Positive staining

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● E-cadherin patterns include no staining (similar to lobular), full staining (similar to ductal) or staining of ductal areas only (Am J Clin Pathol 2001;115:85)

Differential diagnosis

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● Tubulolobular carcinoma

● Collision of two separate neoplasms

End of Breast – Malignant, Males, Children > Mixed ductal and lobular carcinoma

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