Breast – Malignant, Males, Children - Mammary intraepithelial neoplasia (MIN)

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Breast-malignant, males, children

Morphologic variants of DCIS

Mammary intraepithelial neoplasia (MIN)

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 19 August 2009

Last major update: August 2009

Terminology

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● A general term to include both ductal and lobular intraepithelial neoplasia (Am J Surg Pathol 1991;15:209)

● Mammary intraepithelial neoplasia, NOS refers to lesions with intermediate or overlapping ductal and lobular features (Hum Path 2002;33:620)

● Some can be classified based on immunostains as ductal (E-cadherin+, high MW keratin-) or lobular (E-cadherin-, HMW keratin+), but others cannot

● May have classic histological changes of DCIS and LCIS merging in single lobular-duct systems (AJSP 1980;4:241)

● This terminology is also used to describe mouse tumors

End of Breast – Malignant, Males, Children > Mammary intraepithelial neoplasia (MIN)

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