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Breast-malignant, males, children
Morphologic variants of DCIS
Micropapillary DCIS
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 15 August 2009
Last major update: August 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Gross
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● 25% of cases involve multiple quadrants of breast (multicentric)
Microscopic description / grading
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● Elongated epithelial papillary formations projecting into glandular lumen, usually without fibrovascular cores, may have bulbous expansion at tip resembling a club
● Composed of small, uniform cells without necrosis
● Usually low grade
● Associated with flat epithelial atypia (Mod Path 2007;20:1149)
Micro images
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Low power
No true fibrovascular cores Roman bridges
Within a papilloma
Apocrine features
With cribriform DCIS With hypersecretory features
With columnar cell change
Discontinuous fragments related Micropapillae lack fibrovascular
to plane of sectioning cores, cells are homogeneous
Cytology images
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Micropapillary DCIS Micropapillary group from a low grade DCIS
End of Breast – Malignant, Males, Children > Micropapillary DCIS
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