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Breast-malignant, males, children
Metastases to male breast
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 15 April 2010
Last major update: October 2009
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Clinical
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● 2% of all nonhematologic breast malignancies
● Most common primay is melanoma; also prostate, colon, lung and bladder (Virchows Arch 2006;449:507)
● Prostate metastases are often bilateral, usually after estrogen therapy in background of gynecomastia; PSA+, PAP+ (note that the normal male breast and gynecomastia may be PSA+ but PAP-, Breast Cancer Res 2004;6:R18, Hum Pathol 1991;22:242)
● Need strong index of suspicious to diagnose, may need immunostains to distinguish primary and metastatic disease
Radiology
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● Single, round, discrete lesions without spiculation (Acta Cytol 2002;46:377)
Case reports
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Primaries from:
● Bladder (Br J Radiol 2000;73:1326)
● Lung (Australas Radiol 1998;42:16)
● Prostate (Hinyokika Kiyo 1999;45:269)
● Skin eccrine adenocarcinoma (J Cutan Pathol 2007;34:934)
Microscopic description
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● Usually no DCIS or elastosis (J Clin Pathol 2007;60:1333)
Micro images
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Metastases to male papillary breast cancer
Prostate cancer metastatic to breast
Additional references
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End of Breast – Malignant, Males, Children > Metastases to male breast
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