Breast – Malignant, Males, Children - Trabecular variant of lobular carcinoma

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Breast-malignant, males, children

Trabecular variant of lobular carcinoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 13 September 2009

Last major update: September 2009

Definition

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● Classic lobular carcinoma infiltrating in trabeculae (linear bands) two to four cells thick

● Trabecula: supporting beam of bar; plural is trabeculae

● Trabeculae variant is usually not considered a distinct variant because it overlaps the classic and mixed patterns (Schnitt: Biopsy Interpretation of the Breast, 2008)

Electron microscopy

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● Tumor cells are similar to classic lobular carcinoma (J Pathol 1985;145:39)

● Compared to LCIS, tumor cells are more irregular, with more organelles and filaments

End of Breast – Malignant, Males, Children > Trabecular variant of lobular carcinoma

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