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Breast-malignant, males, children
Solid variant of lobular carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 13 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● First described in 1975 (Hum Pathol 1975;6:373)
● Cells grow in sheets that engulf normal structures and infiltrate fat
● Cells have cytologic features of classic lobular carcinoma
● Little intervening stroma present
● Resembles lymphoma
Clinical
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● In 1989, represented 6% of all lobular carcinomas, and had poorest survival of all subtypes (Br J Cancer 1989;60:605)
Case reports
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Micro images
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Diffuse tumor cell infiltration
Solid pattern, but cells are still separate and distinct
Pan-keratin E-cadherin
Differential diagnosis
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● Histiocytoid variant of lobular carcinoma - solid growth pattern, but with foamy to granular cytoplasmic change (Pathol Int 2005;55:353)
End of Breast – Malignant, Males, Children > Solid variant of lobular carcinoma
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