Breast – Malignant, Males, Children - Basal like variant (subset) of invasive lobular carcinoma

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Breast-malignant, males, children

Basal-like variant (subset) of invasive lobular carcinoma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 13 September 2009

Last major update: September 2009

Clinical

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● Invasive lobular carcinoma cases include all molecular subtypes, include basal-like, and basal-like carcinomas include a variety of histologic subtypes (J Pathol 2008;216:141)

● CK5/6 positivity, part of definition of basal-like tumors, is present in 17% of lobular tumors (Hum Path 2008;39:331)

● Associated with grade 3 tumors (50%) and ER negativity, but similar morphology otherwise

Negative stains

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● E-cadherin

End of Breast – Malignant, Males, Children > Basal like variant (subset) of invasive lobular carcinoma

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