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Breast-malignant, males, children
Intralymphatic breast carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 4 October 2009
Last major update: October 2009
Copyright: (c) 2009, PathologyOutlines.com, Inc.
See also angiolymphatic invasion, inflammatory carcinoma
Definition
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● Extensive intralymphatic component with no (pure intralymphatic carcinoma) or only minimal (predominantly pure intralymphatic carcinoma) residual invasive carcinoma (Am J Surg Pathol 2009;33:256)
Clinical
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● Clinically significant pattern of residual disease post chemotherapy; associated with post-chemotherapy nodal metastases
Treatment and prognosis
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● Presence of residual intralymphatic tumor is associated with increased mortality
Gross description
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● Pure cases may have no gross findings
Microscopic description
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● Pure cases have no invasive disease
● Predominantly pure cases have minimal invasive disease
Positive stains
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● D2-40 is helpful to identify lymphatics, although it also stains myoepithelium, particularly in solid DCIS and LCIS (Hum Pathol 2008;39:175)
● E-cadherin is associated with lymphovascular invasion (Cancer 2003;97:2341)
Differential diagnosis
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● Metastatic ovarian serous carcinoma (Breast J 2009;15:176)
End of Breast – Malignant, Males, Children > Intralymphatic breast carcinoma
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