Breast malignant, males, children
Carcinoma subtypes
Intracystic (encysted) papillary carcinoma

Author: Monika Roychowdhury, M.D.(see Authors page)

Revised: 28 December 2016, last major update August 2012

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PubMed search: Intracystic papillary carcinoma [title] breast

Cite this page: Intracystic (encysted) papillary carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantintracysticpapillary.html. Accessed March 29th, 2017.
Terminology
  • Also called encapsulated papillary carcinoma, intracystic papillary ductal carcinoma in situ
Epidemiology
  • Rare; usually seen in elderly women
  • 0.5% - 1% of all breast cancers
  • May be associated with conventional DCIS or invasive carcinoma
Clinical Features
  • Asymptomatic or presents as breast mass or nipple discharge
  • Benign appearance on imaging; on ultrasonography, pure cyst, mixed image or solid mass
  • Can be divided into pure form and those associated with ductal carcinoma in situ (DCIS) or invasive carcinoma
  • Considered noninvasive or minimally invasive, because there is no infiltrating growth pattern and metastases are rare
  • Traditionally considered to lack a myoepithelial layer (Am J Clin Pathol 2005;123:36), but one study found expression of type IV collagen (Am J Clin Pathol 2009;131:228)
  • More difficult to diagnose preoperatively than other breast tumors (Surg Today 2009;39:5)
  • Pseudoinvasion may be due to prior core biopsy causing epithelial displacement (J Clin Pathol 2002;55:780)
Case Reports
Treatment
Gross Description
  • Mural nodule within a large cystic space; may be encapsulated
Gross Images
Images hosted on other servers:

Intracystic hemorrhagic tumor with invasion

Micro Images
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Papillary tumors

Encapsulated tumor with hemorrhage


Papillary and solid pattern of atypical cells

Core biopsy with luminal calcifications

CK 5 / 6 negative

Pseudoinvasion due to epithelial displacement post biopsy

Virtual Slides
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Intracystic papillary carcinoma

Positive Stains
Negative Stains
  • CK 5 / 6, myoepithelial markers except for type IV collagen