Breast – Malignant, Males, Children - Epidermal Growth Factor Receptor

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Breast-malignant, males, children

Epidermal Growth Factor Receptor (EGFR)

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 8 September 2009

Last major update: September 2009

Terminology

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● Also called HER1; related to HER2

Clinical

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EGFR expression is associated with these breast cancers:

● Basal-like (BMC Genomics 2007;8:258)

● Carcinomas with squamous differentiation (87%, Int J Surg Pathol 2005;13:319)

● ER negative tumors (Pathol Res Pract 1988;183:25, Breast Cancer Res 2008;10:R49)

● Metaplastic (76%, Breast Cancer Res 2005;7:R1028)

● Phyllodes tumors (all types-19%, malignant-75%, Lab Invest 2006;86:54)

● Sarcoma NOS (5 of 7, AJSP 2006;30:450)

● Associated with poor survival (J Clin Oncol 2007;25:4405)

● 6% of breast carcinomas show moderate to low level EGFR amplification associated with protein overexpression, and may be responsive to anti-EGFR-therapy (Mod Path 2005;18:1027); EGFR inhibitors have been used for lung cancer patients

Micro images

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IHC and CISH Metaplastic carcinoma - H&E, Phyllodes tumors

EGFR and EGFR-CISH

Spindle cell carcinoma -

EGFR and HER2 overexpression

Molecular images

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Malignant phyllodes tumor

and EGFR amplification

End of Breast – Malignant, Males, Children > Epidermal Growth Factor Receptor (EGFR)

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