Breast malignant, males, children
Carcinoma subtypes
Ductal carcinoma, NOS - pleomorphic variant

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 October 2016, last major update August 2012

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PubMed Search: Pleomorphic carcinoma [title]

Cite this page: Ductal carcinoma, NOS - pleomorphic variant. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantductalNOSpleomorphic.html. Accessed October 18th, 2017.
Definition / general
  • Part of WHO classification
  • Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% or more of tumor cells
Clinical features
  • Aggressive behavior
Case reports
  • 83 year old woman with pleomorphic tumor with predominantly micropapillary features (Pathol Int 2007;57:694)
Microscopic (histologic) description
  • 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
  • Excludes tumors of lobular origin
  • Adjacent DCIS or classic ductal carcinoma in 73%
  • Usually brisk mitotic activity
Microscopic (histologic) images

Images hosted on other servers:

Courtesy of Dr. Semir Vranic

Positive stains
Negative stains
Differential diagnosis
Additional references