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Breast-malignant, males, children
Pleomorphic carcinoma variant of ductal NOS
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 24 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Part of WHO classification
● Variant of high grade ductal NOS with pleomorphic and bizarre tumor cells comprising 50% of tumor cells
Clinical
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● Aggressive behavior
Case reports
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● 83 year old woman with a pleomorphic tumor with predominantly papillary features (Pathol Int 2007;57:694)
Micro
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● Definition: 50%+ of tumor has pleomorphic cell population (> 6X variation in nuclear size) (Histopathology 2000;36:505)
● Excludes tumors of lobular origin
● Adjacent DCIS or classic ductal carcinoma in 73%
● Usually brisk mitotic activity
Positive Stains
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● CAM 5.2, pan-keratin, EMA
● p53 (2/3), S100 (1/3)
Negative Stains
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● ER, PR, bcl2
Differential Diagnosis
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● Sarcoma
End of Breast – Malignant, Males, Children > Pleomorphic carcinoma
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