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Breast-malignant, males, children
Carcinoma with choriocarcinomatous features
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 25 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Part of WHO classification
● Elevated serum beta-hCG and histologic evidence of choriocarcinomatous differentiation
● Rare, < 20 cases reported
Case reports
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● Two cases (Ann Diagn Pathol 2004;8:74)
● Choriocarcinomatous and neuroendocrine features (Sao Paulo Med J 2001;119:154)
Micro images
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Multinucleated giant cells with atypical nuclei Large and bizarre tumor cells are beta hCG+
Non-breast tumor (for comparison)
Cytology description
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● Abundant multinucleated giant cells with highly pleomorphic tumor cells in a hemorrhagic necrotic background (Acta Cytol 2008;52:99)
Positive stains
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● Human placental lactogen, beta-hCG (Breast J 2002;8:244)
Differential diagnosis
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● Metastatic choriocarcinoma to breast (AJR Am J Roentgenol 2005;184:S53)
Additional references
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End of Breast – Malignant, Males, Children > Carcinoma with choriocarcinomatous features
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