Breast – Malignant, Males, Children - Ductal intraepithelial neoplasia (DIN)

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Breast-malignant, males, children

Morphologic variants of DCIS

Ductal intraepithelial neoplasia (DIN)

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 19 August 2009

Last major update: August 2009

Terminology

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● This terminology avoids use of “carcinoma”, but is not widely used

● Proponents claim it reduces the “artificial separation” between ADH and low grade DCIS (Virchows Arch 2006;449:609)

● If DIN terminology is used in a report, recommended to also reference traditional terminology

Microscopic description / grading

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● UDH: usual ductal hyperplasia

● DIN 1A: flat epithelial atypia

● DIN 1B: atypical ductal hyperplasia

● DIN 1C: DCIS grade 1 (low grade)

● DIN2: DCIS grade 2 (intermediate grade)

● DIN3: DCIS grade 3 (high grade)

● Source: Tavassoli: Tumours of the Breast and Female Genital Organs (WHO, 2003)

● Initial version as proposed by Tavassoli is below (Mod Path 1998;11:140), but was subsequently modified to above:

● DIN 1a: usual ductal hyperplasia

● Din 1b: flat epithelial atypia

● Din 1c: ADH and small grade I DCIS

● DIN 2: large grade I and grade II DCIS

● DIN 3: grade III DCIS

End of Breast – Malignant, Males, Children > Ductal intraepithelial neoplasia (DIN)

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