Breast malignant, males, children
Miscellaneous
Treatment effect - Cryoprobe

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 21 December 2016, last major update August 2012

Copyright: (c) 2001-2016, PathologyOutlines.com, Inc.

PubMed Search: breast cryotherapy
Cite this page: Treatment effect - Cryoprobe. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantcryoprobe.html. Accessed July 21st, 2017.
Clinical features
  • Cryoprobe: uses cryotherapy to makes nonpalpable carcinomas well defined and palpable by creating an ice ball, leading to removal of less tissue (Am J Surg 2006;192:462)
  • Alters tumor morphology making it difficult to grade tumor, distinguish DCIS and invasive tumor, and identify angiolymphatic invasion or mitotic figures (Am J Clin Pathol 2007;128:239)
  • Alternative to excision of fibroadenomas (Radiology 2005;234:63)
  • Normal breast parenchyma in cryozone shows dense fibrosis, fat necrosis, xanthogranulomatous reaction, endovascular fibrosis and hemorrhage (Cryobiology 2007;55:44)
  • Causes reduction in ER / PR receptors, but does not affect Ki67 staining or margin evaluation
Microscopic (histologic) images

Images hosted on other servers:

Cryoprobe related
artifact (fig B)
compared to
core biopsy (fig A)

Cellular shrinkage,
smudgy nuclei
and prominent
retraction artifact

Acellular central
hyaline background
without residual
fibroadenoma

Residual invasive ductal carcinoma

Post-cryoprobe ablation
shows coagulative
necrosis and amorphous
eosinophilic staining