Breast – Malignant, Males, Children

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Breast-malignant, males, children

Morphologic variants of DCIS

Clinging DCIS

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 15 August 2009

Last major update: August 2009

Definition

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● Terminology is no longer widely used

● Now usually described as flat epithelial atypia (mild atypia, not considered DCIS, Breast Cancer Res 2003;5:263), atypical columnar alteration or comedo-DCIS (marked atypia and central necrosis)

Microscopic description

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● 1-2 layers of malignant cells lining a gland with a large empty lumen

● Tumor cells often are highly atypical and associated with apoptosis

● Lumina may contain granular intraluminal material with ghosts of tumor cells, resembling comedocarcinoma

Micro images

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Clinging/flat DCIS

Molecular / cytogenetics

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● Loss of heterozygosity identified in 77% (Cancer 2000;88:2072)

References

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● Arch Pathol Lab Med 2009;133:879

End of Breast – Malignant, Males, Children > Clinging DCIS

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