Breast – Malignant, Males, Children - Anaplastic Paget’s disease

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Breast-malignant, males, children

Morphologic variants of DCIS

Anaplastic Paget’s disease

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 19 August 2009

Last major update: August 2009

Definition

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● Few published reports (AJSP 1992;16:1085, J Cutan Pathol 2009;36:374, Turkish Journal of Cancer 2003;33:158)

Gross description

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● Scaling erythematous lesions confined to nipple, but no breast mass

Microscopic description

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● Full thickness epidermal atypia, loss of nuclear polarity, anaplastic cells, intraepidermal acantholysis

● Variable single cells

● Invasive ductal carcinoma in 50% of cases (3 of 6)

Micro images

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H&E, HER2, CK7

Positive stains

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● EMA, CK7

● CEA (50%), AE1-AE3 (50%)

Negative stains

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● Mucicarmine

Differential diagnosis

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● Bowen’s disease - particularly in shave biopsies; dyskeratotic cells, no cleft like acantholysis, no basal cell layer

End of Breast – Malignant, Males, Children > Anaplastic Paget’s disease

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