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Breast-malignant, males, children
Lymphoepithelioma-like carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 12 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Rare in breast, more common in pharynx
Terminology
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● Not part of WHO breast classification
Epidemiology
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● Usually older patients
Case reports
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● 47 year old woman (Virchows Arch 2005;447:653)
● 50 year old woman with coexisting lymphocytic mastitis (Archives 2001;125:669)
● 65 year old woman (Mod Path 1994;7:129)
● HPV33+ tumor (Hum Path 2008;39:298)
Gross description
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● Multiple nodules, without circumscription
Microscopic description / grading
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● Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
● Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
● Occasional mitotic figures
● Lymphoid cells “cuff” large cells in rosette-like manner
● Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
● Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma
Micro images
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Various images
Bladder
High grade tumor cells in sheets and nests AE1/AE3 #1 #2
Positive stains
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● Keratin (AE1/AE3, CAM5.2), EMA
Negative stains
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● EBV (Breast 2004;13:522)
● Usually ER, PR, HER2 and E-cadherin (Ann Diagn Pathol 2004;8:309)
Differential diagnosis
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● Medullary carcinoma - circumscribed, syncytial growth pattern
End of Breast – Malignant, Males, Children > Lymphoepithelioma-like carcinoma
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