Breast malignant, males, children
Carcinoma subtypes
Lymphoepithelioma-like carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 28 December 2016, last major update August 2012

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PubMed search: lymphoepithelioma-like carcinoma breast

Cite this page: Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantLEL.html. Accessed March 29th, 2017.
Definition / General
  • Rare in breast, more common in pharynx
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Usually older patients
Case Reports
Gross Description
  • Multiple nodules, without circumscription
Micro Description
  • Dense inflammatory infiltrate of mature round lymphocytes and lymphoid follicles with occasional plasma cells, histiocytes and eosinophils
  • Also single large cells with abundant pale cytoplasm, large vesicular nuclei, prominent nucleolus and infiltrative pattern at margin of tumor
  • Occasional mitotic figures
  • Lymphoid cells "cuff" large cells in rosette-like manner
  • Tumor cells are occasionally pleomorphic and multinucleated with lymphophagocytosis
  • Also lobulocentric lymphoid infiltrate in hyalinized, sclerotic stroma
Micro Images
Images hosted on other servers:

Various images

Bladder: high grade tumor cells in sheets and nests; AE1 / AE3



Nature.com images:

Lympho-
epithelioma-like
carcinoma

Strong cytoplasmic staining

Positive Stains
Differential Diagnosis
Additional References