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Breast-malignant, males, children
Basal cell carcinoma of nipple
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 8 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Terminology
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● Not in WHO breast classification
● See also Skin-Nonmelanocytic tumors chapter
Epidemiology
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● Very rare (< 50 cases reported), usually age 60+ years, equal distribution between men and women
Clinical
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● May behave aggressively with axillary nodal metastases
Treatment and prognosis
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● No consensus - wide local excision, mastectomy, radiation therapy
Case reports
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● 59 year old man with metastatic tumor to axillary nodes (Archives 1986;110:761)
● 67 year old man (Archives 2004;128:792)
● 74 year old woman (Ann Saudi Med 2007;27:296)
Clinical images
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Fungating, ulcerated, bleeding mass
Microscopic description / grading
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● Proliferating nests of basaloid cells arising from epidermis and extending into superficial dermis and nipple stroma
● May involve underlying lactiferous ducts
Micro images
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Various images Basaloid cells arising Palisading of basal cells
from dermis
Nodules of basal cell carcinoma
Skin-not nipple:
Superficial tumor
Differential diagnosis
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● Paget’s disease - tumor cells are large with clear cytoplasm, not basaloid
● Bowen’s disease - in situ disease without invasion; cells typically are not basaloid
End of Breast – Malignant, Males, Children > Basal cell carcinoma of nipple
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