Breast malignant, males, children
Carcinoma subtypes
Basal cell carcinoma of nipple

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 23 December 2016, last major update March 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: Basal cell carcinoma [title] nipple

Cite this page: Basal cell carcinoma of nipple. PathologyOutlines.com website. http://pathologyoutlines.com/topic/breastmalignantBCCnipple.html. Accessed March 29th, 2017.
Definition / General
Epidemiology
  • Very rare (< 50 cases reported), usually age 60+ years, equal distribution between men and women
Clinical Features
  • May behave aggressively with axillary nodal metastases
Case Reports
Treatment
  • No consensus - wide local excision, mastectomy, radiation therapy
  • Patients should be followed up for primary site recurrence and axillary metastasis as there is greater incidence than with BCC at other anatomical sites (Dermatol Surg 2009;35:1771)
  • Photodynamic therapy proposed as an alternative in superficial tumors (Onkologie 2010;33:613)
Clinical Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Fungating, ulcerated, bleeding mass

Pigmented lesion

Micro Description
  • Proliferating nests of basaloid cells arising from epidermis and extending into superficial dermis and nipple stroma
  • May involve underlying lactiferous ducts
Micro Images
Images hosted on PathOut server:

Skin - not nipple: superficial tumor

Adenoid, courtesy of Dr. Mark R. Wick

Infiltrative, courtesy of Dr. Mark R. Wick

Courtesy of Dr. Mark R. Wick


Courtesy of Dr. Mark R. Wick

Courtesy of Dr. Mark R. Wick

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Various images, H&E

Nodules of basal cell carcinoma

Pigmented lesion

Differential Diagnosis
  • Paget's disease: tumor cells are large with clear cytoplasm, not basaloid
  • Bowen's disease: in situ disease without invasion; cells typically are not basaloid