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Breast-nonmalignant
Foreign body reaction of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 26 September 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Foreign body giant cell inflammation that usually is localized, and occurs 1-2 weeks after trauma, surgery or radiation
Terminology
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● See also Fat necrosis, Reactive spindle cell nodule of breast, Silicon breast implants
● Also called biopsy site changes
Epidemiology
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Sites
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Etiology
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Clinical features
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● Clinically resembles carcinoma due to skin retraction
Prognostic factors
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Case reports
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Due to injections:
● Carbon for biopsy tracking (Clin Radiol 1998;53:845)
● Gear oil (Indian J Pathol Microbiol 2007;50:373)
● Hydrophilic polyacrylamide gel (Hong Kong Med J 2007;13:137)
● Paraffin (Breast 2006;15:540)
● Petroleum jelly (South Med J 2008;101:422)
Treatment
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Clinical images
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Gross description (Macroscopy)
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● Localized to subcutaneous tissue
● May be nodular, fibrotic, orange-brown (due to hemosiderin)
● Up to 1 cm
Gross images
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Micro description (Histopathology)
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● Not encapsulated
● Fibrosis, foreign body giant cells, chronic inflammatory cells, fat necrosis, calcification, cholesterol clefts (needle like empty spaces, due to substances dissolved during processing), hemosiderin
● May see a foreign body
Micro images
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Fibrosis and multinucleated giant cells
Small blood vessel proliferation and giant cells
Collagen plug inside biopsy cavity
Other images: asteroid body; granulation tissue
Drawings
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Virtual Slides
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Foreign body reaction to silicone
Videos
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● (link to topic)
Additional references
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End of Breast-nonmalignant > Foreign body reaction of breast
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