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Breast-nonmalignant

Foreign body reaction of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 26 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Foreign body giant cell inflammation that usually is localized, and occurs 1-2 weeks after trauma, surgery or radiation

 

Terminology

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● See also Fat necrosis, Reactive spindle cell nodule of breast, Silicon breast implants

● Also called biopsy site changes

 

Epidemiology

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Sites

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Etiology

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Clinical features

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● Clinically resembles carcinoma due to skin retraction

 

Prognostic factors

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Case reports

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Due to injections:

● Carbon for biopsy tracking (Clin Radiol 1998;53:845)

● Gear oil (Indian J Pathol Microbiol 2007;50:373)

● Hydrophilic polyacrylamide gel (Hong Kong Med J 2007;13:137)

● Paraffin (Breast 2006;15:540)

● Petroleum jelly (South Med J 2008;101:422)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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● Localized to subcutaneous tissue

● May be nodular, fibrotic, orange-brown (due to hemosiderin)

● Up to 1 cm

 

Gross images

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Micro description (Histopathology)

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● Not encapsulated

● Fibrosis, foreign body giant cells, chronic inflammatory cells, fat necrosis, calcification, cholesterol clefts (needle like empty spaces, due to substances dissolved during processing), hemosiderin

● May see a foreign body

 

Micro images

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Fibrosis and multinucleated giant cells

 

 

Small blood vessel proliferation and giant cells

 

                               

Collagen plug inside biopsy cavity

 

Post-gunshot wound

 

Other images: asteroid bodygranulation tissue

 

Drawings

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Virtual Slides

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Foreign body reaction to silicone

 

Videos

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Foreign body reaction

 

Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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● (link to topic)

 

Additional references

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End of Breast-nonmalignant > Foreign body reaction of breast

 

 

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