Breast - nonmalignant
Benign tumors / changes
Chondrolipoma of breast

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 1 October 2015, last major update October 2015

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Chondrolipoma [title] breast
Definition / General
  • Rare circumscribed lesion of mature fibrous stroma, white adipose tissue, breast ducts and mature cartilage
  • Terminology
  • Also called chondroid lipoma (but these tumors are formed by cartilage associated with white and brown fat)
  • See also Soft Tissue Chapter > Chondroid lipoma
  • Epidemiology
  • Very rare
  • Pathophysiology
  • Considered as cartilaginous metaplasia in lipomas of large size and long standing duration (Goldblum: Enzinger and Weiss's Soft Tissue Tumors, 6th Edition, 2013)
  • Clinical Features
  • Clinically resembles fibroadenoma but may show calcification on mammography mimicking carcinoma
  • Generally seen above the age of 50 years
  • Case Reports
  • 55 year old woman with left breast lump (J Sci Soc 2012;39:147)
  • 58 year old woman with progressively increasing right breast mass (Nig J Surg Res 2001;3:185)
  • 66 year old woman with benign chondrolipomatous tumor (Arch Pathol Lab Med 1977;101:149)
  • Chondrolipoma of the breast (Arch Pathol Lab Med 1989;113:369)
  • Treatment
  • Excision; does not recur
  • Gross Description
  • Well demarcated, islands of cartilage project from cut surface, resembles fibroadenoma (Breast 2006;15:425)
  • Gross Images
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    Hand mass

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    Shoulder mass

    Micro Description
  • Mature fibrous stroma, adipose tissue, breast ducts, mature cartilage
  • Micro Images

    Hand mass:

    Soft tissue (not breast) - AFIP:

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    Well circumscribed tumor composed of clusters of small to medium cells with vacuolated cytoplasm; mature fat cells are present

    Cytology Description
  • Mixture of benign adipose tissue with lipoblast-like cells and chondroblast-like cells with a fibrochondroid matrix
  • Molecular / Cytogenetics Description
  • Seemingly balanced t(11;16)(q13;p12-13) reported in two cases (Am J Surg Pathol 2000;24:1035)
  • Also three way arrangement with chromosomes 1, 2 and 5 (at other sites, Am J Surg Pathol 1999;23:1300)
  • Molecular / Cytogenetics Images
    Missing Image

    t(11;16)(q13;p12-13), 3-way arrangement
    with chromosomes 1, 2 and 5

    Differential Diagnosis
  • Liposarcoma: infiltrative; lipoblasts (may also be found in chondrolipoma) and atypia are present; different cytogenetics