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Breast-nonmalignant
Benign tumors / changes
Chondrolipoma of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 6 October 2012, last major update March 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Rare circumscribed lesion of mature fibrous stroma, white adipose tissue, breast ducts and mature cartilage
Terminology
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● Also called chondroid lipoma (but these tumors are formed by cartilage associated with white and brown fat)
● See also Soft Tissue Chapter-chondroid lipoma
Epidemiology
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● Very rare
Etiology
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Clinical features
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Prognostic factors
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Case reports
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● 66 year old woman (Archives 1977;101:149)
● Detected by mammography (Archives 1989;113:369)
Treatment
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● Excision; does not recur
Clinical images
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Gross description (Macroscopy)
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● Well demarcated, islands of cartilage project from cut surface, resembles fibroadenoma (Breast 2006;15:425)
Gross images
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Hand mass Shoulder mass
Micro description (Histopathology)
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● Mature fibrous stroma, adipose tissue, breast ducts, mature cartilage
Micro images
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Hand mass
Soft tissue (not breast) - AFIP: well circumscribed tumor composed of clusters of small to
medium cells with vacuolated cytoplasm; mature fat cells are present
Virtual Slides
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Videos
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Cytology description
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● Mixture of benign adipose tissue with lipoblast-like cells and chondroblast-like cells with a fibrochondroid matrix
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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● Seemingly balanced t(11;16)(q13;p12-13) reported in two cases (Am J Surg Pathol 2000;24:1035)
● Also three way arrangement with chromosomes 1, 2 and 5 (at other sites, Am J Surg Pathol 1999;23:1300)
Molecular / cytogenetics images
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Hand mass shows t(11;16)(q13;p12-13) and
three way arrangement with chromosomes 1, 2 and 5
Differential Diagnosis
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● Liposarcoma: infiltrative; lipoblasts (may also be found in chondrolipoma) and atypia are present; different cytogenetics
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Chondrolipoma
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