Home   Chapter Home   Jobs   Conferences   Fellowships   Books

 

 

Advertisement 

 

Breast-nonmalignant

Benign tumors / changes

Chondrolipoma of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 6 October 2012, last major update March 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

=========================================================================

● Rare circumscribed lesion of mature fibrous stroma, white adipose tissue, breast ducts and mature cartilage

 

Terminology

=========================================================================

● Also called chondroid lipoma (but these tumors are formed by cartilage associated with white and brown fat)

● See also Soft Tissue Chapter-chondroid lipoma

 

Epidemiology

=========================================================================

● Very rare

 

Etiology

=========================================================================

 

Clinical features

=========================================================================

 

Prognostic factors

=========================================================================

 

Case reports

=========================================================================

● 66 year old woman (Archives 1977;101:149)

● Detected by mammography (Archives 1989;113:369)

 

Treatment

=========================================================================

● Excision; does not recur

 

Clinical images

=========================================================================

 

Gross description (Macroscopy)

=========================================================================

● Well demarcated, islands of cartilage project from cut surface, resembles fibroadenoma (Breast 2006;15:425)

 

Gross images

=========================================================================

 

               

Hand mass                           Shoulder mass

 

Micro description (Histopathology)

=========================================================================

● Mature fibrous stroma, adipose tissue, breast ducts, mature cartilage

 

Micro images

=========================================================================

 

         

 

      

Hand mass

 

 

                                   

Soft tissue (not breast) - AFIP: well circumscribed tumor composed of clusters of small to

medium cells with vacuolated cytoplasm; mature fat cells are present

 

Virtual Slides

=========================================================================

 

Videos

=========================================================================

 

Cytology description

=========================================================================

● Mixture of benign adipose tissue with lipoblast-like cells and chondroblast-like cells with a fibrochondroid matrix

 

Cytology images

=========================================================================

 

Positive stains

=========================================================================

 

Negative stains

=========================================================================

 

Electron microscopy descriptions

=========================================================================

 

Electron microscopy images

=========================================================================

 

Molecular / cytogenetics description

=========================================================================

● Seemingly balanced t(11;16)(q13;p12-13) reported in two cases (Am J Surg Pathol 2000;24:1035)

● Also three way arrangement with chromosomes 1, 2 and 5 (at other sites, Am J Surg Pathol 1999;23:1300)

 

Molecular / cytogenetics images

=========================================================================

 

Hand mass shows t(11;16)(q13;p12-13) and

three way arrangement with chromosomes 1, 2 and 5

 

Differential Diagnosis

=========================================================================

Liposarcoma: infiltrative; lipoblasts (may also be found in chondrolipoma) and atypia are present; different cytogenetics

 

Additional references

=========================================================================

 

End of Breast-nonmalignant > Benign tumors / changes > Chondrolipoma

 

 

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.

 

All information on this website is protected by copyright of PathologyOutlines.com, Inc.  Information from third parties may also be protected by copyright.  Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).