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Breast-nonmalignant

Benign tumors / changes

Carney’s syndrome

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 6 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Autosomal dominant syndrome of myxomas / myxoid lesions in skin, subcutis and breast (Am J Surg Pathol 1991;15:713)

● Also considered a familial multiple neoplasia and lentiginosis syndrome

● Also spotty pigmentation present from birth, endocrine overactivity, psammomatous melanotic schwannomas, and intraductal breast adenoma composed of long, straight, narrow, roughly parallel tubules with distinct epithelial and myoepithelial cells (Am J Surg Pathol 1991;15:722)

● Linked to PRKAR1A gene (Atlas of Genetics and Cytogenetics) at 17q23-24 (found in 46% of Carney’s syndrome cases) and CNC2 gene at 2p16 (J Med Genet 2003;40:268)

First described in 1985 by J. Aidan Carney (Medicine (Baltimore) 1985;64:270, WhoNamedIt.com)

 

Terminology

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● Also called Carney complex

 

Epidemiology

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● Incidence of 70 cases per 100,000 individuals

● Usually white, no gender preference

● Mean age at diagnosis is 10-20 years (eMedicine)

 

Sites

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Etiology

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Clinical features

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Prognostic factors

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Case reports

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Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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Micro images

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Drawings

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Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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Gene Reviews

 

End of Breast-nonmalignant > Benign tumors / changes > Carney’s syndrome

 

 

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