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Breast-nonmalignant
Benign tumors / changes
Benign stromal spindle cell tumors (BSSCT)
Reviewer: Nat Pernick, M.D.
Revised: 6 October 2012, last major update April 2010
Copyright: (c) 2010, PathologyOutlines.com, Inc.
Definition
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● Tumors composed of benign spindle cells, with variable lines of differentiation
● First described by Toker (Cancer 1981;48:1615)
● Terminology used in Tavassoli: Tumors of the Mammary Gland (AFIP Fascicle, 4th series, volume 10); 2009
Terminology
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● Myofibroblastoma: BSSCT with predominant myofibroblastic differentiation
● Spindle cell lipoma: BSSCT with predominant adipocytic component
● Solitary fibrous tumor / hemangiopericytoma: BSSCT with predominant fibroblastic elements
Epidemiology
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Sites
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Etiology
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● Mesenchymal tumors composed of cells capable of various lines of differentiation, including fibroblasts, myofibroblasts, adipocytes and smooth muscle cells
● Histologic variations reflect the features seen in the four types of myofibroblasts: V-vimentin, VA-vimentin and actin, VAD-vimentin, actin and desmin and VADM-vimentin, actin, desmin and myosin (Am J Surg Pathol 1998;22:141)
Clinical features
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● Benign
Prognostic factors
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Case reports
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Treatment
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Clinical images
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Gross description (Macroscopy)
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● Solid, noncystic, well circumscribed
Gross images
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Micro description (Histopathology)
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Micro images
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Drawings
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Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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● Vimentin, CD34, bcl2, CD10, CD99, smooth muscle actin, desmin
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Myoepithelial carcinoma, spindle cell subtype: nuclear atypia, mitotic figures, necrosis, keratin+
● Myofibrosarcoma: mitotic figures and necrosis
● Sarcomatoid carcinoma: may have hemangiopericytoma-like vascular pattern, but also nuclear atypia, frequent and atypical mitotic figures, necrosis
● Spindle cell myoepithelioma: no collagen bundles, keratin+
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Benign stromal spindle cell tumors
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