Bone
Osteosarcoma
Pagets disease associated osteosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Paget disease associated osteosarcoma
Cite this page: Pagets disease associated osteosarcoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/bonepagetosteo.html. Accessed August 16th, 2017.
Definition / general
  • Usually associated with polyostotic Paget disease
  • Multicentric tumors associated with increasing localized pain
  • Much older age than conventional osteosarcoma
  • Very poor prognosis, with death due to pulmonary metastasis or local extension
  • Sites: pelvis, humerus, femur, tibia, skull
Radiology description
  • Paget disease and destruction
Radiology images

Images hosted on Pathout server:

CT scan - contributed by Dr. Mark R. Wick

Xray - contributed by Dr. Mark R. Wick

Gross images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Microscopic (histologic) description
  • High grade sarcoma (osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma) with osteoclasts and atypical osteoblasts
Microscopic (histologic) images

Images hosted on Pathout server:
Missing Image

Osteosarcoma arising in Paget disease

Paget disease of bone with secondary osteosarcoma - contributed by Dr. Mark R. Wick



Images hosted on other servers:
Missing Image

High grade sarcoma

Additional references