Bone marrow - nonneoplastic
Infectious / inflammatory
Penicillium marneffei

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 July 2017, last major update December 2006

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PubMed Search: Bone marrow Penicillium marneffei

Cite this page: Penicillium marneffei. PathologyOutlines.com website. http://pathologyoutlines.com/topic/bonemarrowpenicilliosis.html. Accessed August 22nd, 2017.
Definition / general
Treatment
  • Amphotericin B and itraconazole
Microscopic (histologic) description
  • Normo or hypercellular marrow
  • Intracytoplasmic organisms similar to histoplasma but also sausage cells with light blue cytoplasm and central cross walls (due to fission, not budding) and 1 or 2 purple red small nuclei
  • Normal or increased granulocyte and erythroid precursors
  • Normal megakaryocytes
Microscopic (histologic) images

Images hosted on other servers:

Spleen

Giemsa stain: septate yeast-like cells

Penicillium (A / C)
vs. Histoplasma
capsulatum
(B / D)

Skin: basophilic
microbes and nucleated
basophilic granules

Positive stains
Differential diagnosis
  • Histoplasmosis: budding, intracellular only, no septum; often different epidemiology