Bone marrow - nonneoplastic
Infectious / inflammatory
Cryptococcus

Author: Dragos Luca, M.D. (see Authors page)

Revised: 12 July 2017, last major update January 2014

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PubMed Search: Cryptococcus [title] bone marrow

Cite this page: Cryptococcus. PathologyOutlines.com website. http://pathologyoutlines.com/topic/bonemarrowcryptococcus.html. Accessed October 19th, 2017.
Definition / general
  • Fungal infections are rare in bone marrow and peripheral blood, usually associated with immunosuppression including HIV (Pathol Res Pract 2004;200:591)
  • Cryptococcosis has been reported in transplant recipients but Candida and Aspergillus are much more frequent
  • Immunosuppressive drugs (e.g. Infliximab) increase the risk of cryptococcal infection
Case reports
Microscopic (histologic) description
  • Cryptococcal infection in bone marrow, like other fungal infections, typically shows granuloma formation with or without associated central necrosis (J Infect 2000;41:92, Malays J Pathol 2003;25:69)
  • In patients with underlying immunodeficiency, a diffuse histiocytic hyperplasia without distinct granuloma formation may be seen
  • Organisms may be apparent on routine preparations but their identification is enhanced with GMS, PAS, mucicarmine
  • Has thick capsule (Zhonghua Nei Ke Za Zhi 2005;44:902), may have hemophagocytosis (J Infect 1998;36:118)
Microscopic (histologic) images

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H&E

GMS stain