Bone & joints
Other tumors
Liposclerosing myxofibrous tumor
Author: Nat Pernick, M.D.
Last author update: 1 July 2013
Last staff update: 18 January 2022
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Liposclerosing myxofibrous tumor[title]
Table of Contents
Definition / general | Radiology description | Microscopic (histologic) description | Additional referencesCite this page: Pernick N Liposclerosing myxofibrous tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/boneliposclerosingmyxofibrous.html. Accessed April 25th, 2024.
Definition / general
- Also called polymorphic fibroosseous tumor of bone
- Mixture of lipoma, fibroxanthoma, myxoma, myxofibroma, cyst formation, fat necrosis, ischemic ossification and fibrous dysplasia-like features
- Mean age 40 years but also teens to 60’s
- Usually incidental findings, but may gradually enlarge causing fracture, or occasionally undergo malignant transformation
- Sites: 80% involve proximal femur; also ileum, humerus, rib
- Some of these cases may be a variant of fibrous dysplasia with similar mutations (Hum Pathol 2003;34:1204)
- 10% have malignant transformation
Radiology description
- Well-defined, lytic lesion with sclerotic margin, resembling bone infarct
Microscopic (histologic) description
- Fat, xanthoma cells, cementum-like ossicles, Paget-type bone, myxofibrous tissue with cystic change
- Curvilinear trabeculae in fibrous tissue in some cases
Additional references
