Bone
Other tumors of bone
Fibrosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: fibrosarcoma [title] bone

Cite this page: Fibrosarcoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/bonefibrosarcoma.html. Accessed September 23rd, 2017.
Definition / general
  • Age 40 years or older, no gender preference
  • Sites: medulla of metaphysis of long bones, usually distal femur or proximal tibia, jaw
  • Often secondary to infarct, Paget disease, radiation
  • Occasionally is multicentric, but metastatic sarcomatoid carcinoma (kidney or other sites) is more likely
Radiology description
  • Osteolytic, soap bubble appearance
  • Invasive or well defined margins depending on differentiation of tumor
Radiology images
Images hosted on PathOut server:

Humerus xray - contributed by Dr. Mark R. Wick

Radius

Prognostic factors
  • High grade cytology (10 year survival 34% versus 83% for low grade)
Treatment
  • Amputation, wide local excision
Gross description
  • Fish flesh appearance of sarcomas
  • May destroy cortex and extend into soft tissue
Gross images
Images hosted on PathOut server:

Well circumscribed tumor

Microscopic (histologic) description
  • Resembles soft tissue fibrosarcoma with herringbone pattern of spindle cells with variable anaplasia
  • No malignant osteoid
  • Classify as malignant fibrous histiocytoma if prominent pleomorphism
  • Well differentiated tumors are hypo- or hypercellular with mitotic figures and atypia
  • High grade tumors have more hyperchromasia and mitotic figures
  • May have small cells simulating Ewing / PNET
  • Other variants are sclerosing epithelioid and myofibroblastic
Microscopic (histologic) images
Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Well differentiated

Grade 2

Grade 3