Bone
Other tumors of bone
Desmoplastic fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: desmoplastic fibroma [title] bone

Cite this page: Desmoplastic fibroma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/bonedesmoplasticfibroma.html. Accessed December 15th, 2017.
Definition / general
  • Rare, benign / borderline behavior; bony counterpart of soft tissue fibromatosis
  • 75% younger than age 30 years, may be more common in males
  • Sites: metaphysis of long bones (56%), mandible (26%), pelvis (14%)
Radiology description
  • Lytic and honeycombed (“soap bubble” appearance) metaphyseal lesions, cortical thinning with soft tissue extension
Case reports
Treatment
  • Wide local excision to prevent otherwise frequent recurrences
  • Causes local destruction, no metastases
Gross description
  • White gray, fibrous rubbery mass with variable bony spicules and cysts
Microscopic (histologic) description
  • Mature, bland fibroblasts separated by abundant collagen with thin walled, dilated vascular channels
  • May infiltrate into soft tissue
  • No necrosis, no pleomorphism or atypia, no mitotic activity
Microscopic (histologic) images
Images hosted on other servers:

Bland spindle cells infiltrating into soft tissue

Molecular / cytogenetics description
  • Trisomy 8, trisomy 20
Electron microscopy description
  • Predominantly myofibroblasts, also fibroblasts and primitive mesenchymal cells
Additional references