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Definition
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Epidemiology
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Clinical features
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Prognostic factors
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Treatment
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Clinical images
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Cystoscopy

Gross description
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Gross images
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Multifocal papillary tumors

Micro description
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Micro images
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Series of high grade tumors

Grade 3 tumor resembles papilloma at low power, but nuclear anaplasia is apparent at high power

Highly pleomorphic cells with voluminous cytoplasm

Total architectural disorganization and cytologic atypia

Nuclei are significantly enlarged

Polymorphism and loss of polarity

Pleomorphism and loss of polarity

H&E, CD44, CK20

Fig G-I: H&E, Survivin, Ki-67

CD31

Malignant squamous and/or glandular epithelium

Positive stains
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Negative stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Bladder > Urothelial neoplasms-noninvasive > High grade papillary urothelial carcinoma


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