Benign tumors
Sessile serrated polyp

Reviewer: Jaleh Mansouri, M.D. (see Authors page)

Revised: 23 February 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Sessile serrated polyp appendix
Cite this page: Sessile serrated polyp. website. Accessed July 22nd, 2017.
Definition / general
  • Also known as sessile serrated adenoma or serrated polyp with abnormal proliferation
  • Recently described entity with characteristic morphologic and genetic abnormalities (Am J Clin Pathol 2010;133:623); may include prior cases of focal mucosal hyperplasia
  • Shares some overlapping features with serrated lesions of colon with risk of malignant transformation
  • Exhibits mutations of BRAF and loss of mismatch repair enzymes
  • Microscopic (histologic) description
  • Closely resembles hyperplastic polyp but displays irregular crypt branching (horizontal axis) and dilation and serration of crypt bases, mature mucinous cells at base of crypts
  • Microscopic (histologic) images

    Images hosted on other servers:

    Appendiceal serrated lesions

    Differential diagnosis
  • Hyperplastic polyp: no irregular crypt branching
  • Adenoma (conventional): dysplasia present but no irregular crypt branching